For the past few decades, fast urbanization and big urban sprawl phenomena took place due to an increase in population, migration, globalization, and European integration. This caused a rise in land and property prices together with inner-city problems. Faced with the need to accommodate a growing number of inhabitants in major European cities and capitals, this research aims to establish a multi-criteria methodology that identifies potential Urban Densification zones and facilitates decision-making. The Brussels-Capital Region in Belgium which is projected to have an increase of 190,000 inhabitants by 2040 is chosen as a case study. An inventory was carried out by COOPARCH-RU team at the same time of the development of the Regional Plan for Sustainable Development (PRDD) of the BCR.