According to the most recent Hospital Discharge Records from the Italian Ministry of Health, in the decade from 2008 to 2018 there were about 135’000 new lower limb amputations (LLA), entailing that every year there are approximately more than 12’000 new LLA, of which 1100 transtibial and 3300 transfemoral. The evolution of lower limb prostheses began with passive devices (mechanical and microprocessor prosthesis), and then developed on powered devices, which fully provide for all motor functions of the lower limb, particularly during activities in which energy expenditure becomes prohibitive, such as walking uphill, climbing stairs, and getting up from a chair.