Amyotrophic Lateral Sclerosis (ALS) is an extremely disabling pathology that leads to complete paralysis in a short time. In particular, the patient could reach a condition known as "Locked-In Syndrome" (LIS), in which all voluntary movements are prevented (or "Complete Locked-In Syndrome", if also ocular movements are compromised). In this state, communication with the outside world is impossible and support strategies are required. The disease affects only upper and lower motor neurons, whereas other neurological functions remain unchanged. The pupillary activity is under the control of the Autonomic Nervous System (ANS), whose functions do not appear to be affected as the disease progresses.