Atherosclerosis is the major cause of death and disability in developed countries. It is a progressive disease affecting main arteries due to a chronic inflammation of the tunica intima, with the formation of an atherosclerotic plaque. If the plaque protrudes into the vessel lumen, narrowing the artery, it may impede blood from flowing to downstream organs and tissues. The atherosclerotic disease results from a complex interplay of systemic, biological, and biomechanical factors. Among the latter, local hemodynamics, and, in particular, wall shear stress (WSS) magnitude and topology contribute to the initiation/progression of the disease. Additionally, mass transport in arteries also plays a key role in vascular diseases.