Laura Cornacchia
Development and characterization of microparticular controlled release system for angiogenesis enhancement.
Rel. Gianni Coppa, Luca Salvatore, Nunzia Gallo. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2022
Abstract
The human body has the natural ability to heal itself in many ways. Regenerative Medicine goes beyond the typical diseases management procedures to search for, develop and apply new effective therapies to support the human body to better repair, regenerate or restore injured tissues and organs. The enhancement of wound healing has ever been a Regenerative Medicine goal. Chronic, non-healing wounds are a persistent issue that increases morbidity rates and healthcare costs. A key aspect of many non-healing wounds is the reduced presence of vessel growth. Thus, angiogenesis, a complex sequence through which new capillaries and vessels are formed, is one of key regenerative processes.
The aim of this work was to develop and optimize a microspheres-based (µS) drug delivery system (DDS) for the sustained release of two selected pro-angiogenic factors (AF): i) L-Lysine (K), an essential ammino acid, chosen for its ability to control the inflammation degree and promote angiogenic processes by a ligand-receptor binding mechanism; and ii) cell secretome (S), derived from human mesenchymal cardiac cells (hCmPCs), chosen for its immuno-modulatory and pro-angiogenic potential
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