In recent years, systems based on micro and nanoscale resonators have shown their potential as mass sensors with unparalleled sensitivity: yoctogram mass resolution has been reached using the smallest carbon nanotube resonators, proportionally decreasing with increasing resonator mass. The measurements obtained with these devices have the additional advantage of being intrinsically time resolved, as the resonator response is, at any given time, directly linked to the mass on the resonator. These features make them well-suited for the study of biological samples and ultimately processes (the latter is done by monitoring mass changes in the system, an example use case would be measuring the concentration changes of a specific protein during a cellular reaction); however this introduces the need to work in liquid, which drastically reduces the resonator's sensitivity because of the fluid's damping.