The vibration and instability experienced in an ambulance can lead to secondary injury to a patient and discourage a paramedic from emergency care. So good comfort performance is very importance for the fast riding ambulance. In this thesis, the lumped parameter method is applied to build the 7 DOF mathematical model in terms of comfort behavior of the vehicle. The accuracy of the model was verified by comparing the results of the model to a full vehicle multi-body model from Trucksim software. To optimize the comfort performance of ambulance, based on the 7 DOF model obtained before, the 8 DOF ambulance model was built by using Newton Law.