Cancer is one of the leading causes of death around the globe. Existing drugs and treatments have made substantial progress and improved patients’ life expectancy; nevertheless, it is impossible to overlook that they yield serious adverse effects. A novel strategy is required to overcome these flaws, and electromagnetic fields have appeared to be a promising candidate. In recent years, their exploitation has taken hold more and more, with the benefits of fewer side effects, higher efficiency, a wide range of uses at lower costs. Here we investigate the application of two kinds of electromagnetic fields: terahertz radiation and near-infrared excitation. In particular, we examined the effect that these types of emissions have on microtubules, critical cytoskeletal structures that regulate a wide range of biological functions as cell division, shaping, motility and intracellular transport.