Coronary arteries play a crucial role in blood circulation by providing a continuous supply of oxygen and nutrients to the heart. Due to systemic factors and the presence of local haemodynamic factors, coronary arteries can be prone atherosclerotic plaque formation, which can lead to vessel obstruction. The implantation of an intravascular stent at the narrowed coronary artery is one of the main procedures used in the presence of advanced atherosclerosis. Notwithstanding its advantages, the presence of a non-biological device causes an inflammatory response within the artery. Indeed, the stent leads to a geometric change within the vessel, acting as a barrier to flow and influencing the fluid dynamic behaviour in regions close to the arterial wall, potentially leading to adverse events, such as in-stent restenosis or thrombosis.