Marco Daghero
One-dimensional computational hemodynamics modelling of healthy and diseased coronary arteries.
Rel. Diego Gallo, Claudio Chiastra. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2021
Abstract
Coronary artery disease (CAD) is one of the main causes of mortality in the developed countries. CAD is caused by the formation of atherosclerotic plaques in the arterial wall that progressively narrow the coronary vessel, potentially leading to severe events such as myocardial infarction. The study of hemodynamics is crucial to relate causes and effects of atherosclerosis, early detect and quantify stenoses, design stents and plan surgical interventions. Nowadays, computational fluid dynamics (CFD) models are widely used to investigate blood flow and pressure in healthy and diseased coronary arteries in addition to in vivo measurements and in vitro experiments. Since the solution of three-dimensional (3D) CFD models often requires excessive computational time, one-dimensional (1D) hemodynamic models have been increasingly applied, thanks to their several orders of magnitude lower computational complexity.
In this context, the aim of the present thesis work is to computationally explore the advantages and limits of 1D models of healthy and diseased coronary arteries created with the open-source CFD software SimVascular by comparing the hemodynamic results with those obtained with corresponding 3D models
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