Hemodynamics plays a crucial role in understanding vessel wall disorders, so a quantitative study of hemodynamics is of paramount importance. A strong medical research focus is put on the study of the hemodynamics of coronary arteries, since approximately one-third of the deaths related to cardiovascular issues are due to atherosclerosis affecting the coronary artery walls. Computational fluid dynamics (CFD) is a widely used method of performing a quantitative analysis of the hemodynamics inside blood vessels. However, CFD presents several uncertainties related to the imposition of non-fully specific boundary conditions, which has an impact on simulation results and, subsequently, on the wall shear stress (WSS)-based descriptors used for quantitatively assessing some features of the blood flow.