Ludovica De Franco
In silico mechanical standard tests of a transcatheter aortic valve with anti-embolic filter.
Rel. Alberto Audenino, Claudio Chiastra, Dario Carbonaro, Diego Gallo. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2021
Abstract
Aortic stenosis is a narrowing of the aortic valve opening caused by calcium formation on the native leaflets of the valve, which alter the normal blood circulation. This pathology is one of the most common cardiovascular diseases in North America and Europe. Currently, there is no pharmacological treatment that inhibits the progress of the pathology and usually the stenotic native valve is surgically replaced with a biological or mechanical prosthesis. Transcatheter aortic valve (TAV) implantation is a minimally invasive alternative to open-heart surgical valve replacement. This technique represents the only possibility for about a third of patients with severe aortic stenosis in advanced age that are not eligible for surgical treatment.
However, TAV implantation is still associated to several problems related to post-operative recovery that limit its effectiveness, including an increased risk of stroke
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