Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Affecting millions of people, Myocardial Infarction (MI) and Heart Failure (HF) are the major causes of death among CVDs. MI provokes the massive cardiomyocyte (CMs) loss in the infarcted zone followed by a progressive remodeling of left ventricle. CMs death triggers an inflammatory response followed by the proliferation of cardiac fibroblasts (CFs) in the ischemic region and their differentiation into cardiac myofibroblasts (MyoFs). These events lead to the extracellular matrix (ECM) components overdeposition and tissue stiffening, impairing cardiac function and resulting in cardiac fibrosis. Due to the limited regenerative capacity of native CMs, cardiac tissue cannot self-renew and restore its normal function after an injury.