COVID-19 is a complex viral disease that spread around the world in the early part of the year 2020, becoming a pandemic in March and overloading the health care systems of most of the world's nations. SARS-CoV-2 is the pathogen responsible for the disease and, like other coronaviruses, is composed of 4 structural proteins: nucleocapsid (N) protein, spike (S) glycoprotein, envelope (E) protein, membrane (M) protein. Even in the presence of effective vaccines, it is very important to have a good contact tracing system, able to monitor and control virus circulation and its new dangerous variants. Moreover, in the presence of a high number of infections, the gold standard qRT-PCR test is not able to properly support the requested demand of tests, due to the need for reagents, specialized personnel and laboratory facilities.