Stefano Parlani
A Comprehensive Investigation of a Drug Delivery System for Biomedical Purpose: Diffusion of Curcumin in PLGA Microcarriers from Molecular Dynamics to Continuum FEM.
Rel. Matteo Fasano. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Meccanica, 2021
Abstract
Drug delivery systems have been been recently shown as promising technologies for the biomedical research. In this contest, the study of specific carriers that allow drugs to obtain the maximum benefit for the medical treatment from their chemical properties has found in PLGA, Poly-lactic-co-glycolic acid, one of the most adaptable material for diverse delivery needs. Curcumin is an easily available drug with several advantageous medical applications (but insoluble in water). Disparate studies have been done regarding the loading of Curcumin molecules in PLGA microcarriers to allow in-body diffusion for such insoluble drug. The work "Porous discoidal polymeric particles for effective drug delivery minimizing phagocytosis" done by Susmita Aryala and colleagues from the Department of Biomedical Engineering at Yonsei University, has been taken as reference for this research.
The aim of this study is to move the first steps in the definition of the effective phenomena that rule the Curcumin diffusion in PLGA carriers
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