Complications connected to the surgical pocket represent a serious issue that is able to limit functionality and success of medical implants (in particular, CIEDs so Cardiovascular Implantable Electronic Devices). On the long run, the usage of an innovative material, micro-structured bio-synthesized cellulose, is able to prevent lots of these issues by means of the optimization of the interface between the device and human tissues, inducing an implant protection from fibrotic tissue entrapment (foreign body reaction). Moreover, immediately after the implantation has been successfully, the controlled release of active biological model(mainly antibiotics) ensures further protection from complications, especially in the acute phases of the inflammatory response.