In architectural and structural design, current modeling and analysis tools are extremely powerful and allow one to generate and analyze virtually any structural shape. However, most of them do not allow designers to integrate structural performance as an objective during conceptual design. As structural performance is highly linked to architectural geometry, there is a need for computational strategies allowing for performance-oriented structural design in architecture. Today more than ever, the success of optimization is highly dependent on Artificial Intelligence (AI) techniques. Thanks to these techniques, calculation tools can actively interact with the design process by directing the designer to the development of alternatives that show more compliance with project requirements and to search for solutions increasingly oriented to an optimized behavior of the final configuration.