This thesis work was centred on the processes of mission design and attitude optimization for a lunar constellation of micro-satellites aimed at providing real-time communication and navigation services to surface and orbiting users, as part of the ANDROMEDA project by Argotec. Starting from the mission’s envisioned contribution to the global effort of further exploring the Moon and establishing sustainable human outposts, the main objectives of ANDROMEDA were defined. These represented the fundamental elements driving the mission design, whose process is reported in detail, leading from a preliminary orbital configuration study to an optimized, consolidated system architecture. An overview of the lunar environment is then presented to show its peculiar set of forces and disturbance effects on a satellite’s trajectory and attitude.