Digital innovation in healthcare is embraced with a slower pace with respect to other industries inducing overdue considerations. First, there is a trend consisting of shifting from national healthcare assistance to the private health solutions, because they can integrate much needed technology faster increasing patients’ quality of care. In second instance, the actual care model working for the traditional health sector is outdated. Patients show a need to be active actors in their health. They want to be able to control, at least partly, what regards their wellbeing. The thesis here presented is the effort dedicated to the development of a mobile health architecture and its implementation guide, dedicated to improving the quality of life of patients suffering from chronic diseases.