Gae Azzara
Establishing the rationale for the design of an enhanced mRNA vaccine based on hybrid nanosystems: use of lipid-coated nanoparticles.
Rel. Valentina Alice Cauda, Salvador Borros Gomez, Cristina Fornaguera Puigvert. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2021
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Abstract
According to the World Health Organization, cancer is a large group of chronic, difficult-to-treat diseases with more than ten million new cases each year, and it still remains the second leading cause of death in the world. In addition to mortality, it is also a significant cause of morbidity, due to the problems caused by traditional treatments, such as surgery, radiotherapy, chemotherapy, or a combination of these methods. In recent years, research is strongly focused on finding new therapies that are effective and mostly with a lower incidence of side effects, among the latter, cancer immunotherapy is gaining attraction. Immunotherapies include various approaches among which treatment vaccination with tumor antigens that allows for increased antigen presentation to enhance the ability of the patient's immune system to mount an immune response against neoplastic cells.
This project is the result of a collaboration between IQS of Barcelona and the Politecnico di Torino
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