Climate change and fossil fuel depletion are urging all industrial sectors to reduce the use of non-renewable energy sources and replace them with renewables. The management of gas pipeline networks and, in particular, gas pressure reduction stations (PRS) represent a niche with good potential to increase energy efficiency. PRSs are plants connecting the international high-pressure pipeline network, operating at about 60 bar and managed by the State-owned company SNAM, to the local low-pressure network, operating at about 5 bar and managed by local companies. The expansion operated at PRS causes a temperature drop of gas, even below 0 °C, which could damage pipelines.