Nowadays, healthcare increasingly relies on medical equipment: from being a selection criterion when hospitals purchase new equipment, to improving patient safety through design, usability has become a central factor in the medical device market. Usability engineering tackles the open conversation on the consequence of a human error in healthcare and kickstarted a new way of improving patient safety through user-centered design. Human factor engineering’s role is to investigate what caused the user-error, and the usability engineering’s role is to provide a design solution to minimize its occurrence. To eliminate potential harm is unrealistic, but by factoring in the human element within the design process, the manufacturer can mitigate use-related risk.