The marked predisposition to develop atherosclerotic lesions, that narrow the coronary arteries affecting cardiac perfusion and which is associated risk of myocardial infarction make the coronary arteries an anatomical region of high clinical interest. The simultaneous presence of atherosclerotic lesions and disturbed flow in anatomical regions with more complex geometry such as arterial bifurcations has suggested that hemodynamic stresses play an important role in the pathogenesis of atherosclerosis. In this context, the computer aided engineering, coupled with medical imaging, which allows to perform patient-specific computational fluid dynamics (CFD) simulations is finding a wide application to identify possible link between local flow patterns and the development of atherosclerotic plaques in coronary arteries.