According to some epidemiological studies, one-third of the global population is highly susceptible to motion sickness. The main reason for this disease is assigned to the mismatch between the real and the perceived motion. People suffer this kind of conflict that can be characterized by different symptoms, such as nausea, pallor, cold sweating, increased salivation and stomach awareness. The sensitiveness to this disease can be debilitating. This thesis work addresses the identification of motion sickness disease. An in-depth analysis of the available literature on motion sickness disease has been carried out, with attention to the physiological signals that are usually analysed in this context and that show a physiological reaction to the felt disease.