Schistosomiasis is a tropical disease caused by a worm of the genus Schistosoma that infects around 230 million people worldwide, predominantly children living in poor rural areas of Sub-Saharan Africa. The demand for improving the identification of promising drugs is particularly high in the field of neglected tropical diseases, where funding and commercial investments are typically low. In addition to drug efficacy, information on pharmacodynamics is becoming tremendously urgent to enable the discovery of fast-acting compounds. Fast pharmacodynamic properties, low toxicity and long-lasting effects represent key parameters for the selection of highly promising compounds among potential leads during the in vitro screening process.