Among synovial joints, the knee is one of the most complex, and the one most at risk of osteoarthrosis, a chronic degenerative disease that affects cartilage and subchondral bone tissue. This thesis is the starting point of a research project of the Computational Bioengineering Laboratory of Istituto Ortopedico Rizzoli in Bologna, that aims to develop a subject-specific Finite Element model of the knee joint (SSFE-K), to be prospectively applied to the understanding of the onset of joint cartilage degeneration. The aim of this thesis was to: -Replicate a gold standard modelling procedure, identified in Bolcos et al. 2018; -Address convergence problems, including sensitivity to meniscal geometry, to achieve model robustness, a major issue in SSFE-K; -Obtain cartilage stress/strain results in a physiological loading condition and indirectly validate these results against literature data.