Cardiovascular diseases (CVDs) represent one of the major burdens to the healthcare systems and are the leading cause of death worldwide. Appropriate medication can enable the patients to overcome the disease and improve their quality of life. However, discovery and development of new drugs is a slow and costly process, with cardiotoxicity representing not only one of the most serious causes of attrition during drug development but also a dangerous side effect induced by several medications. Historically the study of the cardiac tissue and the development of new treatments have been hindered by the heart’s lack of accessibility and poor regenerative capacity.