In the last century the Industrial Revolutions brought, in the manufacturing industry, not only new technologies for products and processes but also different systems for the organization of work. The latter is the planning, management and organization of work within an organization in order to reach economic and business development but also to improve productivity, innovation and working conditions. Moreover, new fields of science have been explored bringing also new approaches and methodologies for work risk assessment. In fact, the importance and observation of working conditions has increased considerably leading to the foundation of ergonomics. This new science, introduced in the Second Industrial Revolution, is the assessment of physical and psychological conditions of workers, executed to identify which are the most appropriate characteristics for designing devices and systems for human use.