At present, the necessity to find a solution to environmental impacts derived from the whole life cycle of plastics, from extraction of fossil resources to disposal, has led to a great attention towards bioplastics. Among them, promising candidate has been seen in Polyhydroxyalkanoates (PHAs), which are both biobased and biodegradable, and have a great potential in consumer goods applications. However, their high production cost make their scaled-up manufacturing and market share still marginal. This work provides an overview on the current state of the art of PHA production in order to identify well-established aspects, as well as future challenges that should be overcome to foster the replacement of plastic by biopolymers.