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Biomaterials functionalization with polyphenols and characterization

Virginia Alessandra Gobbo

Biomaterials functionalization with polyphenols and characterization.

Rel. Silvia Spriano, Sara Ferraris, Martina Cazzola. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2020

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Polyphenols are a class of biomolecules that are becoming more and more relevant in scientific world thanks to their antioxidant, antimicrobial and anti-inflammatory properties. Their potentiality in bettering the actual materials applied in musculoskeletal implantology has been deepened. Four biomaterials have been used as substrates to implement functionalisation with polyphenols: hydroxyapatite, titanium and two different types of bioglass. The objective of this research is to study the properties of the functionalising solutions and the treated biomaterials, evaluating a future clinical application. Different characterisation techniques have been used: Folin and Ciocalteu test, UV spectroscopy, FTIR-ATR, zeta potential and fluorescence microscopy. The antioxidant activity has been evaluated through DPPH test. Finally, a release test was implemented, followed by the evaluation of the behaviour of the functionalised biomaterials after sterilisation through gamma irradiation.

Relators: Silvia Spriano, Sara Ferraris, Martina Cazzola
Academic year: 2019/20
Publication type: Electronic
Number of Pages: 240
Corso di laurea: Corso di laurea magistrale in Ingegneria Biomedica
Classe di laurea: New organization > Master science > LM-21 - BIOMEDICAL ENGINEERING
Aziende collaboratrici: UNSPECIFIED
URI: http://webthesis.biblio.polito.it/id/eprint/13755
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