urpose Loosening of the tibial component after total knee arthroplasty is a common indicator of revision. The aim of this thesis is to select and evaluate the parameters that can damage or reinforce the primary interaction between acrylic cement - tibial tray. Methods A prior analysis of the state of the art has allowed us to identify the most in¿uential parameters in the bond between cement and metal. The de¿nition of the parameters was based on the variables that modify the properties and surface conformation of the materials in use. Some parameters required preliminary tests to be quanti¿ed. The in¿uence of the parameters was evaluated by testing the interface of interest with a tensile test.