Spray freeze-drying of pharmaceuticals In the pharmaceutical industry, freeze-drying technology is often used in medicines production since it ensures a more stable product both during shipping and storage. The lyophilized product strongly depends on how the freezing process is carried out. The final morphology, physicochemical properties and efficacy of its active principle all depend on this critical step. Therefore attention has to be given in the design of proper freezing and how it affects the dried product features by predicting the average size of solvent crystals formed. More specifically, we focus on Spray Freeze Drying, the most advanced and common way to perform lyophilization on both food and pharmaceutical products.