Chronic conditions such as rheumatoid arthritis, diabetes, and hypertension affect 80% of US population over 65 years of age, accounting for 66% of all deaths and 75% of healthcare expenditures. The high healthcare cost is mostly due to the focus on acute episodic care rather than continuous management. Moreover patient difficulty in adherence to strict dosing schedules threatens therapy efficacy. Conventional delivery approaches such as oral or parenteral, usually lead to a peak in plasma drug concentration that could reach toxic levels. This peak is usually followed by an exponential decrease in concentration which results in a short efficacy window. On the other hand, a constant and sustained release at the therapeutic concentration level, has been shown to increase treatment efficacy.