The safety of operators in Factories is a key problem since the Industrial Revolution. The growth of the technology let the development of new safety monitoring systems, often integrated with the industrial machinery itself. However, with the Factory 4.0 machines became gradually more autonomous and so the role of the worker has shifted towards the maintenance and the malfunctions management of these ones. The main goal of the future society should be to understand the meaning of this new interaction and to exploit the technology not only for improving performances, but also for protect the safety and the security of the operator.