This study investigates the potential of a Vacuum Pressure Swing Adsorption (VPSA) process that produces high purity streams of H2 and CO2 , with high recovery for both, starting from syngas (mainly hydrogen, carbon dioxide and impurities such as methane, carbon monoxide and nitrogen). The goal of the work is twofold: on the one hand, the scale-up of the VPSA technology is investigated for single cycle H2 and CO2 purification processes to test its effect on technical performances; on the other hand, the scaled process is evaluated from an economic perspective. Concerning the technology scale-up, the analysis starts from a process which is currently operated at the lab-pilot scale and whose key performance indicators are well defined.