Cell transplantation is an attractive strategy to treat endocrine disorders as it is a dynamic and stimulus-responsive system where cells serve as sensors that secrete molecules in response to their environment to maintain homeostasis. The main challenge of cell encapsulation is attaining appropriate vascularization of the graft, which is imperative for preserving cell function and viability, while maintaining sufficient immune evasion to ensure graft survival. To meet this need, we developed a 3D-printed cell encapsulation system comprised of a cell reservoir separated from a drug reservoir by nanoporous membranes for sustained local release of immunosuppressant with loading ports for transcutaneous drug and cell loading.