The recent developments in the manufacturing process and the entry of new privates companies in the space segment are feeding the in-space manufacturing theme. The development of a technology that combines manufacturing and assembly capabilities, practicable in a space environment, is a necessary step to improve safety and to reduce the cost of future space explorations and many other activities. The Additive Manufacturing, between the several technologies tryied in space, is the one that for different reasons, guarantee the highest percentage of success. The operations that can be performed are many: manufacturing and assembly of large-structures, systems’ components, servicing, repair, and many others.