Coronary artery diseases are one of the most common causes of death in developed countries, in particular atherosclerotic stenosis caused by formation of fibro adipose plaques or calcifications, that lead to a narrowing in vessel lumen. This reduction leads to a decrease in perfusion of downstream regions and could subsequently lead to ischemic phenomena and myocardial infarction. Standard procedure for diagnosis of atherosclerotic lesions are invasive, but in recent years, image-based hemodynamic models obtained from computed tomography images combined with computational flow dynamics simulations is becoming a powerful tool, used to calculate descriptors useful to evaluate the fluid dynamic inside blood vessels and its effect on the atherogenesis.