This work presents a novel approach for detecting infections on prosthetic implants via imaging, which is currently a crucial problem in the biomedical sector. For this purpose, a mesoporous titania layer (pore size ~6 nm) was produced via self-assembly of Titanium (IV) Butoxide and Pluronic P123 as templating agent. Its role is to coat a prosthetic device so as to guarantee a functionalised active surface, able to integrate correctly with human tissues as well as, most importantly, to carry a specific contrast agent for MRI in its pores. Iopamidol was selected as a drug for MRI-CEST, which would give birth to a signal that is promptly related to local pH changes in the tissues surrounding the prosthesis.