Federica Lucia Pepe
Multi-stage hybrid antioxidant nanovectors for the treatment of central nervous system pathologies.
Rel. Gianni Ciofani, Christos Tapeinos. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2019
Abstract
Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and cardiovascular diseases, are considered among the most common and above all growing in our society, resulting in a major socio-economic burden [1]. The causes can be related, to external factors such as, environmental factors, ionising radiation exposure, chemical exposure, to endogenous factors, like inflammation, oxidative stress, vitamin deficiencies, smoking, ageing, or even other factors like following a pre-existing pathology such as stroke, diabetes, depression, tumour [2]. A patient with a neurodegenerative loses a large population of neural cells, leading to nervous system dysfunction [3]. Oxygen is essential for life, but it is also potentially dangerous.
There is a complex system of production and control of the balance of oxygen and also of its reactive species, like hydroxyl radicals (• OH), hydrogen peroxide (H2O2), superoxide radicals (• O-2) and hypochlorite (ClO-)
Relatori
Anno Accademico
Tipo di pubblicazione
Numero di pagine
Informazioni aggiuntive
Corso di laurea
Classe di laurea
Aziende collaboratrici
URI
![]() |
Modifica (riservato agli operatori) |
