Microtubules are cylindrical protein filaments formed by dimers of tubulin. They are fundamental in many cellular functions, such as mitosis, which is a key process in the cellular multiplication. Because of this central role, they are an interesting target of pharmacological treatment, as it is possible to block the mitotic process by altering the dynamic equilibrium between microtubule’s polymerization and depolymerization. From this perspective, it is interesting to design and develop antitumoral drugs able to selectively bind the tubulin in the tumoral cells, in order to lead them to apoptosis. There are several tubulin isotypes: in particular, tumoral cells are characterized by an overexpression of αβIII tubulin, so a drug able to specifically target this dimer can be assumed as a good drug to target tumoral cells.