Alessandra Pecora
Texture analysis in metastases of patients affected by metastatic differentiated thyroid carcinoma treated with 131I.
Rel. Andrea Lavagno. Politecnico di Torino, Master of science program in Energy And Nuclear Engineering, 2019
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Abstract
In metastatic differentiated thyroid cancer (MDTC) the radioiodine treatment is a consolidated approach. The effectiveness of the therapy can be verified on post administration tomography imaging. Aim of this study is to evaluate the feasibility and prognostic impact of 131I SPECT-CT images features analysis (FA) performed on metastatic lesion in MDTC patients. FA is performed on SPECT-CT images with a free software (LIFEx, CEA 2017) taking into account texture features (TF) and first-order features (FF). TF include Gray-Level Occurrence Matrix GLCM (e.g. homogeneity, contrast) and Gray-Level Zone Length Matrix GLZLM (e.g. HGZE); FF include histograms indices (e.g. skewness, kurtosis and entropy).
On a spheres phantom (NEMA PET IEC) filled with liquid 131I (13 MBq/ml), SPECT-CT images (at 3, 120, 160, 216 h after preparation) were acquired
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