Biomimetic mesoporous silica nanoparticles for drug delivery in a synthetic lethality approach. In the recent years, the scientific community has payed a growing attention on nanotechnology, which is the use of materials with a dimension range in the nanometer size. In particular, the application of nanotechnology in medicine, “Nanomedicine”, is increasingly important, because the small size of nanomaterials allows their easy interactions with biomolecules and cells. Furthermore, nanomaterials have several physical and chemical features that can be used in different medical fields, such as imaging, therapy and drug delivery. Concerning the drug delivery, the Nanoparticles (NPs) with pores of different size are of particular interest, thanks to their high cargo capability, high surface area and the possibility to functionalize the surface for several purpose.