Antonio Pellico
Design and fabrication of piezoelectric cardiac patches with auxetic geometry for myocardial repair.
Rel. Valeria Chiono, Michael Monaghan. Politecnico di Torino, Corso di laurea magistrale in Ingegneria Biomedica, 2025
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Abstract
Myocardial infarction (MI) is a major contributor to global mortality, impairing heart function by inducing extensive loss of cardiomyocytes and isolation of the remaining cells within a fibrotic scar tissue. Among emerging regenerative pathways, cardiac patches represent a promising approach for myocardial regeneration, as studies have demonstrated their capacity to support cellular regeneration by providing mechanical reinforcement or facilitating electrical conductivity. However, many existing designs fail to integrate both functionalities, which are essential for optimal cardiac tissue repair. Piezoelectric materials are particularly suited for this purpose, due to their ability to generate electrical fields in response to mechanical actuation, and the potential to adapt to match the anisotropic motion of the cardiac chambers.
This research project aims to achieve the integration of both an auxetic patch geometry and piezoelectric functionality in a cardiac patch with tuneable properties, with the dual goal of establishing a pipeline for comparing auxetic designs and laying the groundwork towards the integration of piezoelectric properties
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