The use of multi-electrode arrays (MEAs) has revolutionised the study of neuronal networks in vitro, enabling the simultaneous monitoring of the electrical activity of neurons. This technology is crucial for investigating neurodegenerative diseases such as Alzheimer’s and Parkinson’s and for developing new therapeutic strategies. However, commercial MEA systems are often expensive and offer limited flexibility for custom experimental protocols. Within the framework of the NeuERA project, the eLiONS team (Department of Electronics and Telecommunications) has developed a modular and low-cost acquisition platform specifically designed to perform both amperometric and potentiometric measurements on neuronal signals recorded by an innovative 60-electrode diamond-based MEA.