The Contamination and Collision Avoidance Manoeuvre (CCAM) is the flight phase of Vega-C missions directly after the Payload (PL) release, critical for the insurance of the integrity of the released PL. Its main objectives are to avoid the collision of the upper stage with the separated PL in a mid and long-term and to minimize the pollution of the PL by the plume of the launcher’s motors (Main Engine and ACS Attitude Control System thrusters). Several aspects of the PL separation greatly affect this manoeuvre, above all the launch vehicle’s attitude, PL release direction and the separation mechanism. These aspects, together with specific PL requirements and the possibility of multiple releases on the same orbit, make high variability one of the main characteristics of this flight phase, forcing the mission designer to look for an efficient solution in a custom-made way and making this missionization process highly time-consuming.