The aortic valve is located between the left ventricle and the aorta, and it fulfills the essential function of ensuring unidirectional blood flow from the ventricle to the aorta. The aortic valve is susceptible to diseases such as aortic stenosis and regurgitation, which result in left ventricle overload and potentially heart failure. A common treatment for aortic valve disease is aortic valve replacement, entailing the substitution of the native valve with a mechanical or biological prosthesis. Mechanical aortic valves ensure higher durability with respect to biological ones, but they induce fluid dynamic alterations that increase the risk for thrombosis, hemolysis, and device failure.