The central idea of this thesis is to investigate the safety issues in manufacturing industry. How to create a sustainable environment for industrial activities is the goal of safety investigation. In order to improve the safety climate of the manufacturing plant, we need to start from two macro aspects, one is to try to reduce the equipment malfunctions by scientific management of maintenance activities, the other is to investigate the deep reasons behind the Near Misses and accidents, to reduce the occurrence of the substandard events from the root. In the trend of safety investigation in recent years, the post-accident analysis methodology is not as popular as the preventive investigation, that is, the research on substandard events or Near Misses.