Titanium and its alloys are currently the most widely used materials in dental and orthopaedic implantology. However, they present a number of problems that have clinical consequences. These include the incompatibility between the rigidity of the bone tissue to be replaced and the implant (stress shielding, which causes bone resorption) and the low capacity for osseointegration. The aim of this research work is to propose a solution to both these problems. The first proposal is the realisation of substrates in Ti c.p grade IV through an already consolidated technique, the space holder. Different sizes (100-200 μm and 355-500 μm) of spacer particles (ammonium bicarbonate) are exploited to obtain porosity of different sizes and in different % (30/40/50/60).