Transport of drug molecules through surface micro-structured bio-synthesized cellulose

Complications connected to the surgical pocket represent a serious issue that is able to limit functionality and success of medical implants (in particular, CIEDs so Cardiovascular Implantable Electronic Devices). On the long run, the usage of an innovative material, micro-structured bio-synthesized cellulose, is able to prevent lots of these issues by means of the optimization of the interface between the device and human tissues, inducing an implant protection from fibrotic tissue entrapment (foreign body reaction). Moreover, immediately after the implantation has been successfully, the controlled release of active biological model(mainly antibiotics) ensures further protection from complications, especially in the acute phases of the inflammatory response. In the following report, molecules transport through surface micro-structured bio-synthesized cellulose will be modelled by means of a Finite Elements/Finite Volumes simulation, by taking into account the real geometry of the implantable device, the bio-material layer and of the substrate carrier: furtherly, the transient nature of the controlled release dynamics will be considered. Main aim of the present report is to investigate about bio-synthesized cellulose effect on the transport of various APIs (Active Pharmaceutical Ingredients), mainly the two antibiotics Minocycline and Rifampin, and to create a 3D model that can work like a tool in the design activity of the medical implantable device.